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Welcome to DICL
What is DICL?
The most comprehensive ion channels database
DICL Database Overview
Comprehensive interface for ion channel research data
The Database of Ion Channels and Ligands (DICL) represents the most extensive professional online resource dedicated to ion channels research.
Regularly Updated
Continuously curated with latest research data
Advanced Search
Search by IUPAC, structure, patents, literature
Comprehensive Data
34 data items per record including IC50, EC50, Ki, Kd
Global Coverage
1,750 ion channels from 165 different species
Each data record comprises 34 distinct items including chemical structure, biological activity, target information, and chemical/physical properties, facilitating advancements in scientific research.
Classification of Ion Channel Targets
Understanding the structural and functional diversity of ion channels
Voltage-Gated Ion Channels (VGICs)
Respond to changes in membrane potential
Ligand-Gated Ion Channels (LGICs)
Activated by neurotransmitter binding
Other Ion Channels (OICs)
Specialized channels with unique properties
Overview of Ion Channels
Ion channels are ion-permeable pores located in the lipid membranes of all cells. They open and close in response to various stimuli, regulating the flow of specific small ions.
Classification: Ion channels are generally classified into voltage-gated, ligand-gated, and other ion channels.
Key Statistics
Phylogenetic Tree Analysis
Voltage-Gated Ion Channels Superfamily
The largest superfamily of ion channels consists of tetrameric voltage-gated cation channels and their relatives.
